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We now provide pathophysiological evidence that the conversion of the reduced form of AGT to its more active oxidized form is associated with inadequate antioxidant status and could indeed contribute to the hypertension of pre-eclampsia.

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In this Review, Sankar Ghosh and Matthew Hayden discuss the roles of several newly identified regulators of the NF-B pathway, as well as some old factors that have been assigned new functions.

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