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With consistent dosing of cuprizone for 5 weeks, body weights were significantly affected in C57BL/6NTac versus C57BL/6J mice

Moreover, the acquired resistance of sensitive tissues to radiotherapy is also common (Kim et al., 2015)

Additional biomarkers like neuroinflammatory markers (e.g., TNF, IL6) and genetic variants (e.g., LRRK2, GBA mutations) contribute to early risk stratification [64, 79, 173, 250]

FIGURE 3 On the other hand, the effects of GH and GHR on mitochondrial function are multifaceted, which may be induced by the differences between cell-, organ-, and species-dependent features or various physiological conditions in vivo and in vitro

Table 5 presents the mean and standard deviation of liver enzymes and creatinine levels at the beginning and end of the study for both groups