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Description
Significant sex differences are observed in PD prevalence, with ASPR of 152.88 per 100,000 in males compared with 108.93 per 100,000 in females, yielding a maletofemale ratio ranging from 1.4 to 1.7 [35, 38] (see Table 1)

The timing strategy isn't about preventing pharmaceutical interaction

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Any imbalance towards increased protease expression and activity may lead to overt inflammation and trigger chronic lung disorders such as COPD and emphysema 674,675

Some studies used fasted dosing, others with meals
