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found that Astragalus polysaccharides (APS) could prevent murine colitis and ferroptosis in human Caco-2 cells by inhibiting this signaling pathway.It suggested that ferroptosis may be regulated through the Nrf2 / HO-1 signaling pathway in DSS-induced UC ( Nrf2 and HO-1 was upregulated in DSS-induced UC mice

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Senescent cells adopt an irreversible senescence-associated secretory phenotype (SASP), releasing soluble factors such as interleukins, chemokines, and growth factors 25 , 26

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Lin X, Kang K, Chen P, Zeng Z, Li G, Xiong W, et al

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