glutathione peroxidase production ck Glutathione-Related Enzymes and Proteins: A Review GPX1 (Glutathione Peroxidase, GSHPx) Gene
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Ma M, Kong P, Huang Y, Wang J, Liu X, Hu Y, et al

For example, a study published in the American Journal of Clinical Nutrition found that B12 supplements reduced homocysteine levels and improved heart health in older adults

Moreover, it should be soluble in both water and fat as well as safe in vivo [61]

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multicomponent 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each 3 ml ampoule contains: Thiamine hydrochloride (Vitamin B1) 100,0 mg Pyridoxine hydrochloride (Vitamin B6) 100,0 mg Cyanocobalamin (Vitamin B12) 1,0 mg Sugar free For a full list of excipients, see section 6.1 3 PHARMACEUTICAL FORM Clear, red solution with no visible particles

That is the reason why it is safe to use that within that period and not beyond that
