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Collectively, advancing the mechanistic understanding and therapeutic exploitation of the TAM-ferroptosis axis holds considerable promise for the next generation of precision immunometabolic cancer treatments

To catalyze this oxidoreduction reaction, GLDH, as a typical dehydrogenase, employs cytochrome c (Cyt c) as an electron acceptor, forming a transient (millisecond lifetime) low-affinity protein-protein complex (Hervs et al., 2013), but cannot use molecular oxygen as an electron acceptor because the enzyme has an Ala113 acting as a gatekeeper, which prevents the molecular oxygen from accessing to the isoalloxazine nucleus (Leferink et al., 2009a)

oxysporum infection was markedly increased (Han et al., 2016)

Subsequently, computational modeling and quantitative characterization confirmed that pDox exhibited a high binding affinity for FABP4, facilitating cancer cell uptake through lipid metabolism processes and significantly enhancing drug transport efficiency

T.et al (1999)

However, many of seleniums functions are manifested through different selenoproteins