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they have to be freely circulating in the tissue, in the fluids, and the bloodstream

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Biochemical analyses of cerebrospinal fluid for the diagnosis of neurometabolic conditions

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Interestingly, the actions mentioned above of GR may be modulated by other nuclear receptors specific for certain endocrine tumours, such as androgen receptors (ARs), estrogen receptors (ERs), or progesterone receptors (PRs)

However, larger studies showed no improvements in clinical outcomes (Treeprasertsuk et al., 2003