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The final step in carnitine synthesis that occurs in liver and kidney depends on the enzyme -butyrobetaine hydroxylase, which may be deficient in children

NIH R01 HL098435, HL133497, and HL141155 to A.W.O
263 Other clinical trials have also reported SAMe reduced fibromyalgia pain and depression symptoms

Brain Res 951:330335 Waniewski RA, Martin DL (1998) Preferential utilization of acetate by astrocytes is attributable to transport

J Clin Endocrinol Metab 2001;86:3579-94

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