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Mitochondrial dysfunction destabilizes lysosomes, amplifying oxidative stress and ferroptotic signaling (62)

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Further research on mitochondrial function in the context of DMD may provide novel strategy of treatment and improve quality of life of these patients

How it works: Oral glutathione is extensively degraded by intestinal gamma-glutamyl transferase before reaching systemic circulation the liposomal phosphatidylcholine matrix bypasses this by enabling direct mucosal absorption, delivering intact reduced GSH to systemic and intracellular compartments

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[113] have confirmed that endostar carried by nanoparticles have a better anticancer activity than the conventional delivery system because of the improved release and longer half-life of endostar in target tumour