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As a result, the peak of Gi-F + Cathepsin (CTS) + lysosomalacidllpase (LAL) (pH 5.0) group was similar to that of Gi-F (pH 7.4) group, indicating the high stability of Gi-F in the acidic and enzymatic context of lysosomes (Supplementary Fig

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However, while these mechanistic insights are promising, the translation into robust clinical outcomes remains limited, and current evidence is largely derived from in vitro and animal models (123125)

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