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In vitro studies have demonstrated that DCA can induce apoptosis in colon adenocarcinoma cells, a process mechanistically linked to the generation of oxidative stress and subsequent mitochondrial dysfunction ( Figure 2 illustrates how microbiota-derived bile acids modulate immune cells to foster an immunosuppressive TIMEa central theme of this section

Patients are resistant to corticosteroids and require bronchodilators/antibiotics

L.FinlayJ

Neuroscience 2014;281:68-76

Since the discovery of toxoid vaccines for prevention of tetanus and diphtheria, and the success of treating infections with antimicrobial drugs and antibiotics, the use of antibody therapies has been largely replaced by new and efficient therapies

Seale et al., 2020