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At present, most of these pathways have been studied extensively in malignant tumors, neurological diseases, and liver and kidney injury, except the latter two pathways, which are relatively rarely studied and showing no clear target or index for the treatment or prognosis in each disease

132 Several phytocompounds, such as Sapidolide A, 47 allicin, 133 and berberine, 134 have been shown to inhibit inflammasome activation and alleviate APAP-induced hepatotoxicity

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In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)