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The idea that a lipid-rich substance has the potential to reverse the effects of certain drugs began in the 1960s, when several animal experiments demonstrated that intravenous administration of an oil emulsion decreased the duration of action of thiopental or decreased the free fraction of chlorpromazine in blood

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[DOI] [PubMed] [Google Scholar] 157.Werner A, Bell J

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Cited by GLP-1-based combination strategies for weight loss: Multi-target agents and combination therapies, Pharmacological Research, 230 , (108331), (2026)