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Further, long-term use of acid-reducing drugs and the anti-diabetes drug metformin and repeated exposure to nitrous oxide have been implicated in vitamin B 12 deficiency (see Drug interactions)

doi:10.1210/endo.142.12.8522

There is no evidence that it does, and the case for caution here doesn't actually rest on postpartum depression specifically: it rests on the simple fact that dedicated pregnancy and lactation safety data doesn't exist for AHK-Cu at all