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Elevated SUA activates endothelial NF-B signaling, upregulating monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1) expressions to accelerate atherosclerosis progression (Wang H

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doi: 10.3390/ijms20225674 [DOI] [PMC free article] [PubMed] [Google Scholar] 21

One alternative approach to direct fusion to albumin, in which one would not have the risk of C-terminal end cleavage limiting the therapeutic potential, is by fusing or conjugating GLP-1 or other therapeutic agents to an albumin-binding molecule 7