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found that blocking Gln metabolism can enhance tumor-specific immunity by inhibiting the transcription of CSF3 in tumor cells, which decreases the generation and attraction of MDSCs and stimulates the creation of pro-inflammatory TAMs (42)

Ferroptosis-mediated immune responses in cancer

Am J Physiol Regul Integr Comp Physiol 305:R592R603 Libiad M, Yadav PK, Vitvitsky V, Martinov M, Banerjee R (2014) Organization of the human mitochondrial hydrogen sulfide oxidation pathway

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238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD