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Therefore, while the preclinical foundation for exploring anti-cytokine therapies exists, significant work is required to bridge this to clinical application, including identifying which tinnitus patients exhibit a dominant cytokine-driven pathology that would be amenable to such targeted biologics see in Figure 2 and

Therefore, understanding the dynamics of IL-6 production in CNS lesions may help to predict the effectiveness of STAT3 signaling as a suppressor of lesion pathology

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These aldehydes also activate immune responses by functioning as DAMPs, stimulating dendritic cells and inducing pro-inflammatory cytokines such as IL-6, IL-1, and TNF-, contributing to vitiligos autoimmune component [87]