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3 In addition, the amino acid's breakdown product histamine also plays an essential role in the body, and too low histamine levels also prove to be problematic for health

S2CID 13892871

Shyer JA, Flavell RA, Bailis W

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Intriguingly, the inhibitory effects are mitigated by the treatment with UNC1999 (an inhibitor of H3K27me3) and 5-aza-2-deoxycytidine (a DNA methyltransferase inhibitor) (unpublished data) (58, 60), suggesting methionine or SAM reduces the production of inflammatory factor in association with the histone and DNA methylation modification of specific genes