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While B12 is crucial, the body cannot produce it

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Direct delivery of respiratory drugs to the lungs bypasses systemic circulation, allowing higher local drug concentrations and reduced overall dosage need, thereby minimizing systemic side effects 98,99,108,109,111

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doi: 10.1056/NEJMra1205406

Even more, it has recently been postulated that the restriction of DNA synthesis to the reductive phase of the cycle in yeast may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication [51], which implies the common mechanism of the DNA protection during S phase in all eukaryotes