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Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)

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Furthermore, its short half-life of 20-30 minutes necessitates a 3-times-per-week administration every second week, making it inconvenient for both patients and clinicians