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So a mitochondrial connection to fatigue is common sense

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UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Using a mouse model of ME/CFS but with the NLRP3 gene inactivated, the researchers showed that the mice had reduced fatigue behavior after forced exercise

doi: 10.1056/NEJMoa021778

Riboflavin deficiency has been implicated in preeclampsia a pregnancy-associated complication characterized by elevated blood pressure, protein in the urine, and edema (significant swelling)