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Description
This review delves into the intricate dynamics surrounding both glutamine antagonism strategies and glutamine supplementation within the context of cancer treatment, emphasizing the critical role of glutamine metabolism in cancer progression and therapy
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In addition, ferroptosis is characterized not only by the loss of GPX4 activity and subsequent accumulation of labile iron and excessive ROS production, but also by the peroxidation of polyunsaturated fatty acids (PUFAs) [102,103]
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The eicosanoids, redox-regulated lipid mediators in immunometabolic disorders
The ionotropic glutamate receptors
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The outliers also included EGFR -mutant (PC9, H1650) and FGFR1- amplified (H520) NSCLC and others (H1299, HT-1080), which could be explained by the fact that SLC7A11 was not affected by LDHB KD ( Supplementary Figure 10b, c, d )
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In this capacity retinoic acid is considered a hormone of the steroid and thyroid hormone superfamily
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