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10.1371/journal.pone.0130908 111 QiuY.XuS.ChenX.WuX.ZhouZ.ZhangJ.et al (2023)

Multiple trials have robustly shown a strong association of NNMT with IR and T2D (Liu et al., 2015)

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This review will focus on the roles of NNMT in obesity and T2D, as it has been found that the expression of this methyltransferase is elevated in the white adipose tissue and liver of obese people and diabetic mice and that NNMT knockdown protects against diet-induced obesity and insulin resistance [11]

It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage