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In the United Kingdom, the prevalence of chronic pain ranges from 35% to 51.3% of adults with 10.4% to 14.3% having moderate or severely disabling chronic pain [6]

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It is generally agreed that laminar shear stress promotes the release of factors that suppress inflammation and reactive free radicals production, while low shear stress, turbulent flow, and stasis promote the production of inflammation and thrombosis [4]

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