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doi: 10.1177/17557380231162873 70 AlbanoGD

Two MTHFR genes commonly studied are C677T and A1298C (these labels indicate the mutations appearance and location on the gene)

This transient GSH depletion resulting from glyoxalase system activity may therefore have important consequences for the cell's oxidative stress status [e.g., increasing oxidized glutathione (GSSG)/GSH and NADP/NADPH ratios], since glutathione represents one of the most important antioxidants in mammalian cells (Dringen, It has previously been reported that glutathione concentrations are higher in astrocytes than in neurons (Dringen, Impact of manipulating Glo-1 activity in astrocytes and neurons The observation that exogenous MG is highly damaging to neurons compared to astrocytes raises the question of the capacity of these cells to control intracellular MG production and detoxification

Blood 100(10):38323834

The structures referenced in Fig

Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Horiuchi H, Cheung DL, Nabekura J, Sugita K et al (2021) Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus