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Acknowledgements This work was supported by the Singapore National Medical Research Council (R-174-000-137-275), the Jay and Betty Van Andel Foundation (H Eric XU and Karsten MELCHER), Amway (China) Limited (H Eric XU), and the National Institutes of Health 5R01DK071662-08 (H Eric XU) and GM102545 and GM104212 (Karsten MELCHER)

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Study procedure All participants underwent clinical evaluation and blood sample collection on day 1 and were provided a 7-day supply of supplement or placebo capsules with instructions on their use

Consequently, they can be targeted in migraine preventive and therapeutic strategies

Research protocols employ diverse approaches including isolated mitochondria preparations, permeabilized muscle fiber respirometry, stable isotope tracers for metabolic flux analysis, cellular bioenergetics assays (Seahorse), and in vivo metabolic phenotyping in rodent models