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It mediates antigen-stimulated signaling and facilitates endocytosis, both of which are essential for maintaining B-cell functionality and immune responses [80,81,82]

MRP1 and MRP2 (ABCC2) share 48% of sequence identity and 78% homology and present some similarities in substrate specificity 27

Ben Abdelkader, F

Studies have shown that rhodioloside achieves its functions by modulating the hypoxia-inducible factor-1 signaling pathway, which is a heterodimeric transcription factor expressed in numerous body tissues and is responsible for the induction of erythropoietin (EPO) gene expression under hypoxic conditions [3,4]

In summary, Astragalus species shows great promise as a natural therapy and functional food

10.3390/ijms21228637 82 SedlakT