what does glutathione do nadh metabolism links FOXRED1 to NADH:ubiquinone oxidoreductase (complex I) deficiency: A hypothesis Relumins Age Defense NAD+ Supplement

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FrstermannUMnzelT

doi:10.1097/md.0000000000015566 Li P, Qiu T, Qin C

doi: 10.3109/10408448509037461

doi: 10.1039/d3nr01052j 97 McClelandMLAdlerASDemingLCosinoELeeLBlackwoodEMet al

Graphical Abstract Keywords: Traumatic brain injury, Intranasal drug delivery, Mitochondrial function therapeutics, Blood brain barrier, Neuroprotection Highlights Noninvasive intranasal drugs administration bypass the BBB, and can be rapidly delivered from the nasal mucosa to the brain The intranasal delivery is an attractive route for mitochondria-targeted neuroprotective drugs administration Accurate screening of intranasal compounds based on physiochemical properties is crucial When optimizing the intranasal administration by nanocarriers, drugs protection from chemical and enzymatic degradation must be carefully applied The intranasal route offers means to pharmacologically counter TBI pathogenesis in austere combat settings