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When AGEs bind to receptors known as RAGEs, they activate inflammatory signaling pathways like NF-B and mitogen-activated protein kinase (MAPK) and encourage the expression of fibrotic markers like TGF-1 and fibronectin (FN) in GMCs

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At the same time, NAC and its analogues contribute to the physiological antioxidant activity by acting as a GSH precursor [56,57]

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Cachora is surrounded by mountains and the majestic snow-capped Padreyoc (5571 m.a.s.l.)

Table 6 provides a reference point detailing approved drugs that have been intranasally administered for various medical applications