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50mg produces approximately 4050% enzyme inhibition, while 100mg achieves 6075% inhibition, but the curve plateaus beyond 150mg, suggesting diminishing returns

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doi: 10.1186/1471-2172-10-52

28 In the MONICA/KORA Augsburg surveys, the prevalence of peripheral neuropathy increased from 7.4% in individuals with normal glucose tolerance to 28.0% in those with T2DM as glucose tolerance worsened

In his review in Blood, Ralph Green hematologist, Department of Pathology and Laboratory Medicine, University of California, Davis, recommends at least 10mcg/day of daily vitamin B12 to prevent problems