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the invention encompasses a method of treating an NNMT-expressing cancer such as glioblastoma, by administering a therapeutically effective amount of one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa

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The cells were seeded in a 96-well plate with 2 10 5 cells/ml for 12 h, and a certain amount of WL-1 was added (the final concentration increased gradually in the range of 0250 M)

On the other hand, baseline measurements found that levels of IL-10 in APP/PS1 mice were significantly reduced in comparison to wild type mice, and when treated with Dihexa these mice experienced an increase in IL-10 levels

doi: 10.1007/s11418-009-0330-z

They can recommend whether a trial should continue, be modified, or be terminated, based on safety concerns