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J Immunother 41 (7): 350-358, 2018

NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRIs Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI

These findings are important for optimizing the safe intake of indispensable amino acids in healthy humans and should be useful for future utilization of L-threonine supplementation in individuals for which it is indicated

Regulatory Frameworks Are Central to Peptide Use As interest in peptides has expanded, so has the importance of regulatory oversight