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Description
This inflammatory environment impacts barrier integrity and provides an avenue for the entry of luminal contents into systemic circulation contributing to the development of gut-associated and extraintestinal inflammatory disorders

M.AlbanoM.AlvesF
JAMA, 2020

The selectivity arises because senescent cells are uniquely dependent on FOXO4-mediated p53 sequestration for survival, while non-senescent cells employ multiple redundant anti-apoptotic mechanisms

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