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Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss

In preclinical models, it has demonstrated pro-angiogenic, cytoprotective, and anti-inflammatory properties 1-3

BPC-157 was well-tolerated and exhibited no severe toxic effects in mice, rats, rabbits, and dogs

Hormone Research, 53(6), 274278

David Lee, MD, a physician specializing in obesity management at Stanford University