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Melatonin has also been shown to be effective at the cardiovascular level in lowering blood pressure in humans, type 1 diabetic adolescents (Cavallo et al., Another study showed that melatonin is a valuable therapeutic agent against ischemic stroke related to aging, demonstrating that aged Wistar rats treated with melatonin from 24 h prior to until 7 days after an induced ischemic stroke had a significant reduction in the concentrations of glial fibrillary acidic protein, TNF-, IL-1, Bcl-2-associated death promoter, and Bcl-2-associated X protein in both the hippocampus and brain cortex, while the hippocampal concentrations of sirtuin 1 and Bcl-2 were increased

Gut microbiota and probiotics in modulation of epithelial and gut-associated lymphoid tissue function

In the Model group, the levels of TNF-, IL-6, TLR4, and NF-B (p65) in ovarian tissue were much higher than those in the Control group (Figure 4B)

10.1073/pnas.2208792120 44 DasA.BasakP.PramanikA.MajumderR.GhoshA.HazraS.et al (2020)

Estrogen plays a crucial role in rab9-dependent mitochondrial autophagy, delaying arterial senescence

10.18632/aging.100597 Aging