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Obesity increases the risk of diseases, such as type 2 diabetes mellitus, fatty liver disease, hypertension, myocardial infarction, stroke, dementia, osteoarthritis, obstructive sleep apnea, and several cancers (such as breast, colon, and prostate), thereby contributing to a decline in both quality of life and life expectancy

Biliverdin reductase-A impairment links brain insulin resistance with increased Abeta production in an animal model of aging: implications for Alzheimer disease

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Many patients with CFS also experience nausea, anorexia, dizziness, drenching night sweats, an intolerance to pharmaceuticals (affecting the central nervous system) and alcohol (Afari and Buchwald 2003)

Moreover, the potential of microbial metabolites as biomarkers for early diagnosis and prognosis of CRC is discussed