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This heightened sympathetic tone contributes to the attenuation of the normal nocturnal decline in blood pressure and heart rate, ultimately predisposing individuals to systemic hypertension [6]

However, while downregulation of homeostatic functions and overrepresentation of immune-related pathways was initiated in control astrocytes after TBI, even without any injury, IKK2-CA GFAP astrocytes already showed an aggravation of these features due to NF-B activation per se, an effect which was further boosted by TBI

Oxidative stress plays a significant role in regulating normal wound healing by aiding hemostasis, inflammation, wound closure, and the development and maturation of the extracellular matrix (ECM) [8]

Such split is susceptible to clustering in chemical space, and therefore can result in structurally similar pesticides in both training and testing sets 20,46

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