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It is composed primarily of: Collagen Elastin Glycosaminoglycans Proteoglycans Other structural proteins Following injury to the skin or soft tissues, regeneration involves more than simply producing new cells

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To determine the role of HIF-1 in regulating ECHS1 expression, we used the CRISPR/Cas9 system to knockout the VHL tumor-suppressor protein, which resulted in increased levels of HIF-1 and ECHS1 (Supplementary Fig

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