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Dimeric (inactive) PKM2 creates a constriction through glycolysis at the terminal reaction resulting in the accumulation of glycolytic intermediates [6, 159], which are channeled into other pathways, such as the pentose phosphate pathway, which is an anabolic pathway which generates precursors for nucleotide and aromatic amino acid biosynthesis, all of which are necessary for the rapid proliferation typical of cancer cells

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Low-level laser therapy for beta amyloid toxicity in rat hippocampus

10.1038/s41598-021-93941-y

However, an unintended consequence of this mitochondrial iron restriction could be diminished ferroptosis sensitivity