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The doseresponse associations between OBS and the risk of chronic diarrhea and constipation were assessed using a restricted cubic spline(RCS) with a spline smoothing function

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A small percentage of mice with only one copy of the GPx-1 allele and complete deficiency of GPx-2 develop mild ileocolitis (GPx-1 +/ GPx-2 / ), whereas a single copy of the GPx-2 gene (GPx-1 / GPx-2 +/ ) protects against inflammation, leading to the suggestion that GPx-2 has a greater protective effect in the intestine than GPx-1 (114), although an earlier study reported that one copy of either of these GPx genes was sufficient to prevent the development of intestinal cancer (72)

The carnitine pool also influences mitochondrialnuclear crosstalk