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In untrained individuals, the cerebral circulation exhibits greater sensitivity to reductions (than increases) in mean arterial pressure, demonstrating a greater change in MCAv (and assumingly CBF) during a hypotensive stimulus compared to a hypertensive stimulus (Roy et al., 2022

A scheme of oxidative stress-related pathways in FECD is shown in Fig

This suggests that the combination therapy provides enhanced benefits in managing this specific pattern of DOR

14 However, the data are confounded by past or concomitant use of phototherapy or other immunosuppressive agents

The high-mobility group box-1 (HMGB1) protein is a pro-inflammatory nuclear protein that is passively released and targets Toll-like receptors (TLR) to alert the immune system of dying cells (Lotze and Tracey 2005