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Astrocyte Signature in Alzheimers disease continuum through a multi-PET tracer imaging perspective

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The mechanisms of NP-induced neurotoxicity include the generation of free radicals, immune responses, and neuroinflammation, which can lead to cell necrosis and other adverse effects

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However, it only increases the percentage of the EFSAs acute reference dose (ARfD) of 20 g/kg body weight from 7.4% to 8.9% (lower bound) or from 13% to 15% (upper bound), which is negligible for people with normal kidney function

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