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METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy

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10.1038/s41564-019-0498-2

For example, miR-21 modulates glycolysis in CD4 + T cells through the PTEN/PI3K/AKT pathway, accelerates the cell cycle, promotes CD4 + T cell polarization toward Th2, and induces fibrogenic cytokine IL-13 expression, which participates in arsenite-mediated fibrosis of the liver [110]

Functional Nrf2 is essential for thyroid hormone synthesis in mESC-derived follicles The most important phenotype driven by the lack of Nrf2 is the absence of the Tg-I and T.H