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In addition, it is able to inhibit nuclear factor (NF)-B (a well-known target of liver injury), thereby reducing proinflammatory cytokines (IL-1 and IL-6) and increasing anti-inflammatory cytokines (IL-10), indicating it has anti-inflammatory and anti-necrosis activities [35]

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[PubMed] [Google Scholar] Krzywanski DM, Dickinson DA, et al

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Acknowledgments The authors thank Dimitry Lapage for his guidance on animal feeding experiment and Anneke Ovyn for her guidance on the parameter test in the laboratory

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Additionally, MPP + has high affinity for noradrenergic and serotonergic uptake transporters [6,82], and its precursor, MPTP, has been mainly used in neuronal models with dopaminergic characteristics, such as the dopaminergic neuroblastoma cell line SH-SY5Y [83]

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