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Description
These receptors are thought to act by bridging autophagic cargoes with mAtg8s associated with the nascent autophagosomal/phagophore membrane
Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice
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Higher retatrutide doses (10-12 mg) produce more GI side effects and carry a higher risk of dysesthesia (tingling/numbness) without engaging the amylin pathway
The peptide shows negligible activity at related class B receptors including CRF, PTH, and secretin receptors, supporting its specificity for the incretinglucagon receptor family
Nat Commun 15:5796
