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The ability to tune drug release profiles adds an element of flexibility to this delivery method, paving the way for personalized treatment regimens

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The hypothesis of the gain of function in GCase theorizes that the mutant form of protein is recognized as misfolded, thus placing stress on mechanisms of protein degradation and interfering with -synuclein breakdown and consequent endoplasmic reticulum stress, as observed in autophagy perturbations in cells derived from patients with GBA1 -associated PD (Fernandes et al., 2016)

MBOAT: membrane-bound O-acetyltransferase

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Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle
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