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To further ensure GLUT1 as the molecular target of CDr17, we also generated activated (CRISPRa) and inhibited (CRISPRi) GLUT1 expression in HeLa cell by using CRISPR/dCas9-VPR 22 and -KRAB 23 , respectively (Supplementary Fig

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Previous infection with Wuhan-Hu-1 has been associated with a weaker induction of Omicron-specific nAbs [55], suggesting an imprinting effect