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With off-label use, a drug approved by the FDA is prescribed for a purpose other than what it is approved for

Theyre a popular choice for a reason, but they arent the only optionand for many people, they arent the most effective one

Also called Basivertebral Nerve (BVN) Ablation, it targets the basivertebral nerve inside the vertebral body to interrupt pain signaling from damaged vertebral endplates

In comparison, placebo produced only 3.1% weight loss

Cell 130 , 10951107 (2007)

While no dose adjustment is routinely required, awareness of this pharmacogenomic variability is important, especially when using Esomeprazole in combination regimens