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However, the inclusion of a denaturant, such as SDS, may be necessary to ensure rapid labeling of all free cysteine residues because about 20% of total cellular protein thiols are not susceptible to modification by NEM under native conditions [24]

This interaction not only denotes a competition with CD28 for CD80/CD86 binding but also depletes CD80/CD86 molecules from the cell surface of APCs by trogocytosis [27]

The HOPS/Class C Vps complex tethers high-curvature membranes via a direct protein-membrane interaction

Ferber A, Chang C, Sells C, Ptasznik A, Cristofalo V et al

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

Taking into consideration the limited riboflavin absorption and utilization in 1015% of global population, long term riboflavin insufficiency could participate in the development of multiple neurological disorders, emphasizing the importance of long-term riboflavin-sufficient diet especially in vulnerable populations