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Obstet and Gynaecol Forum (2024) 3:242334

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Activated caspase-9 then activates effector caspases, such as caspase-3 and caspase-7, resulting in the degradation of cellular substrates such as nuclear lamins and poly (ADP-ribose) polymerase (PARP)

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TADs are the first-line drugs for CVS prophylaxis and have been shown to reduce the duration, severity, and frequency of episodes, as well as the number of emergency room visits and hospitalizations.90 Amitriptyline, the TAD of choice, is usually started at a low dose of 25mg and is gradually increased to a target dose of approximately 100mg at night in adults